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IntroductionSample size varies greatly among trials, ranging from tens of patients to thousands of patients,1 even within a meta analysis investigating the same question. For example, a meta analysis in cardiology2 included trials with sizes ranging from 62 patients to 45852 patients. Our knowledge about the influence of trial sample size on treatment effect estimates is based on the small study effect the tendency for small trials to report greater treatment benefits than large trials in the same meta analysis.3 4 5 A study based on a collection of meta analyses in osteoarthritis showed that trials including fewer than 100 patients per arm yielded, on average, greater treatment effect estimates than did larger trials.6
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He has also received a commission from the Lord for leadership in the community. So this is a call to recommit himself. Peter has had his attention fixed on Jesus ever since the Beloved Disciple told him the person on the beach was Jesus, but now he takes his eyes off Jesus and looks at the Beloved Disciple, who is following (v.